It is the year 2019 and the vast majority of the population has been turned into vampires. Only five percent of the world are humans and that leaves the vampires without a sustainable food supply. Lower class vampires are wasting away and reverting into bat-like creatures while the upper class is looking for a blood substitute. Edward Dalton (Ethan Hawke) is a leading hematologist who happens to come in contact with Elvis Cormac (Willem Defoe), a human who has been cured of the vampire virus. Dalton and Cormac work to create a mass cure while being hunted by Charles Bromley (Sam Neill) and his army who don't want to be cured.